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Barbiturates can induce hepatic microsomal enzymes resulting in improved metabolism and lowered anticoagulant response of oral anticoagulants (eg, warfarin, acenocoumarol, dicumarol, and phenprocoumon); clients stabilized on anticoagulant therapy may possibly require dosage changes if barbiturates are added to or withdrawn from their dosage program

Dependence and Addiction – Standard use may result in Bodily and psychological dependence on opioids. This can lead to withdrawal signs and symptoms if use is reduced or stopped.Healthcare Evaluation – Right after stabilization, an intensive health-related analysis ought to be conducted to determine another prospective injuries or complications